SCI260 – Introduction to Biochemistry
Lesson 2
During tonight’s class, we discussed protein structure and how changes in the amino
acid sequence of a protein can significantly alter its function and cause
diseases/disorders. With this in mind, write a paragraph that explains the cause of
sickle cell anemia disease?
Your answer should be no longer than one page and should answer ALL of the following
questions:
1. What is the name (spell it out) of the specific protein that is affected in sickle cell
anemia disease?
2. Describe the specific change in the amino acid sequence that causes sickle cell
anemia disease?
3. How does this protein function in normal people who do not suffer from sickle cell
anemia disease?
4. What are the symptoms that individuals with sickle cell anemia disease experience?
5. Is there a cure for sickle cells anemia disease? If not, describe the types of
treatments that are used to alleviate the symptoms of sickle anemia disease.
You will earn 20 pts for correctly answering each question (maximum points earned is
100). You may use the internet and/or your textbook to assist you, but please DO NOT
copy your answers directly from the internet or textbook.
Expert Solution Preview
Introduction:
In biochemistry, proteins play a crucial role in the proper functioning of the human body. Any changes in the amino acid sequence of a protein can lead to serious diseases and disorders. In this assignment, we will discuss sickle cell anemia disease, a genetic disorder caused by changes in the structure of hemoglobin protein. We will answer each question separately and thoroughly to earn maximum points in this assignment.
Answer:
1. The specific protein affected in sickle cell anemia disease is called hemoglobin.
2. The specific change in the amino acid sequence that causes sickle cell anemia disease is the replacement of the amino acid glutamic acid with valine at the sixth position in the beta-globin chain of hemoglobin.
3. Hemoglobin proteins function in normal people by carrying oxygen from the lungs and distributing it to the tissues and organs throughout the body.
4. Individuals with sickle cell anemia disease experience symptoms such as chronic fatigue, anemia, pain in the chest, back, and limbs, frequent infections, and delayed growth and puberty.
5. Currently, there is no cure for sickle cell anemia disease. However, treatments such as blood transfusions, bone marrow transplants, pain management medications, and hydroxyurea are used to alleviate the symptoms and complications of sickle cell anemia disease.
In conclusion, sickle cell anemia disease is a genetic disorder caused by the changes in the hemoglobin protein structure. It affects the normal functioning of the protein and leads to various symptoms, such as chronic pain, fatigue, frequent infections, and growth delays. Although there is no cure for sickle cell anemia disease, various treatments can alleviate the symptoms and improve the quality of life of individuals suffering from this disease.
